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1.

PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network.

Reichermeier, Kurt M; Straube, Ronny; Reitsma, Justin M; Sweredoski, Michael J; Rose, Christopher M; Moradian, Annie; den Besten, Willem; Hinkle, Trent; Verschueren, Erik; Petzold, Georg; Thomä, Nicolas H; Wertz, Ingrid E; Deshaies, Raymond J; Kirkpatrick, Donald S.

Mol Cell; 77(5): 1092-1106.e9, 2020 03 05.

Artículo en Inglés | MEDLINE | ID: mdl-31973889

2.

TAC-tics for Leveraging Proximity Biology in Drug Discovery.

Nalawansha, Dhanusha A; Mangano, Kyle; den Besten, Willem; Potts, Patrick Ryan.

Chembiochem; 25(4): e202300712, 2024 02 16.

Artículo en Inglés | MEDLINE | ID: mdl-38015747

3.

Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein.

den Besten, Willem; Verma, Kshitij; Yamazoe, Sayumi; Blaquiere, Nicole; Phung, Wilson; Izrael-Tomasevic, Anita; Mulvihill, Melinda M; Helgason, Elizabeth; Prakash, Sumit; Goncharov, Tatiana; Vucic, Domagoj; Dueber, Erin; Fairbrother, Wayne J; Wertz, Ingrid; Yu, Kebing; Staben, Steven T.

J Am Chem Soc; 143(28): 10571-10575, 2021 07 21.

Artículo en Inglés | MEDLINE | ID: mdl-34236858

4.

Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα).

Dragovich, Peter S; Adhikari, Pragya; Blake, Robert A; Blaquiere, Nicole; Chen, Jinhua; Cheng, Yun-Xing; den Besten, Willem; Han, Jinping; Hartman, Steven J; He, Jintang; He, Mingtao; Rei Ingalla, Ellen; Kamath, Amrita V; Kleinheinz, Tracy; Lai, Tommy; Leipold, Douglas D; Li, Chun Sing; Liu, Qi; Lu, Jiawei; Lu, Ying; Meng, Fanwei; Meng, Lingyao; Ng, Carl; Peng, Kaishan; Lewis Phillips, Gail; Pillow, Thomas H; Rowntree, Rebecca K; Sadowsky, Jack D; Sampath, Deepak; Staben, Leanna; Staben, Steven T; Wai, John; Wan, Kunpeng; Wang, Xinxin; Wei, BinQing; Wertz, Ingrid E; Xin, Jianfeng; Xu, Keyang; Yao, Hui; Zang, Richard; Zhang, Donglu; Zhou, Hao; Zhao, Yongxin.

Bioorg Med Chem Lett; 30(4): 126907, 2020 02 15.

Artículo en Inglés | MEDLINE | ID: mdl-31902710

5.

Conjugation of Indoles to Antibodies through a Novel Self-Immolating Linker.

Dragovich, Peter S; Blake, Robert A; Chen, Chunjiao; Chen, Jinhua; Chuh, Josefa; den Besten, Willem; Fan, Fang; Fourie, Aimee; Hartman, Steven J; He, Changrong; He, Jintang; Ingalla, Ellen Rei; Kozak, Katherine R; Leong, Steven R; Lu, Jiawei; Ma, Yong; Meng, Lingyao; Nannini, Michelle; Oeh, Jason; Ohri, Rachana; Lewis Phillips, Gail; Pillow, Thomas H; Rowntree, Rebecca K; Sampath, Deepak; Vandlen, Richard; Vollmar, Breanna; Wai, John; Wertz, Ingrid E; Xu, Keyang; Xu, Zijin; Zhang, Donglu.

Chemistry; 24(19): 4830-4834, 2018 Apr 03.

Artículo en Inglés | MEDLINE | ID: mdl-29493023

6.

Prospecting for molecular glues.

den Besten, Willem; Lipford, J Russell.

Nat Chem Biol; 16(11): 1157-1158, 2020 11.

Artículo en Inglés | MEDLINE | ID: mdl-32747810

7.

Catalytic in vivo protein knockdown by small-molecule PROTACs.

Bondeson, Daniel P; Mares, Alina; Smith, Ian E D; Ko, Eunhwa; Campos, Sebastien; Miah, Afjal H; Mulholland, Katie E; Routly, Natasha; Buckley, Dennis L; Gustafson, Jeffrey L; Zinn, Nico; Grandi, Paola; Shimamura, Satoko; Bergamini, Giovanna; Faelth-Savitski, Maria; Bantscheff, Marcus; Cox, Carly; Gordon, Deborah A; Willard, Ryan R; Flanagan, John J; Casillas, Linda N; Votta, Bartholomew J; den Besten, Willem; Famm, Kristoffer; Kruidenier, Laurens; Carter, Paul S; Harling, John D; Churcher, Ian; Crews, Craig M.

Nat Chem Biol; 11(8): 611-7, 2015 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-26075522

8.

Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2.

Chan, Nickie C; den Besten, Willem; Sweredoski, Michael J; Hess, Sonja; Deshaies, Raymond J; Chan, David C.

J Biol Chem; 289(28): 19789-98, 2014 Jul 11.

Artículo en Inglés | MEDLINE | ID: mdl-24855649

9.

Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking.

Haines, Dale S; Lee, J Eugene; Beauparlant, Stephen L; Kyle, Dane B; den Besten, Willem; Sweredoski, Michael J; Graham, Robert L J; Hess, Sonja; Deshaies, Raymond J.

Mol Cell Proteomics; 11(6): M111.016444, 2012 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-22337587

10.

Ubiquitination of, and sumoylation by, the Arf tumor suppressor.

den Besten, Willem; Kuo, Mei-Ling; Tago, Kenji; Williams, Richard T; Sherr, Charles J.

Isr Med Assoc J; 8(4): 249-51, 2006 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-16671360

11.

Arf induces p53-dependent and -independent antiproliferative genes.

Kuo, Mei-Ling; Duncavage, Eric J; Mathew, Rose; den Besten, Willem; Pei, Deqing; Naeve, Deanna; Yamamoto, Tadashi; Cheng, Cheng; Sherr, Charles J; Roussel, Martine F.

Cancer Res; 63(5): 1046-53, 2003 Mar 01.

Artículo en Inglés | MEDLINE | ID: mdl-12615721

12.

PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress.

Kuo, Mei-Ling; Lee, Mabel Bin-Er; Tang, Michelle; den Besten, Willem; Hu, Shuya; Sweredoski, Michael J; Hess, Sonja; Chou, Chih-Ming; Changou, Chun A; Su, Mingming; Jia, Wei; Su, Leila; Yen, Yun.

Sci Rep; 6: 18846, 2016 Jan 06.

Artículo en Inglés | MEDLINE | ID: mdl-26733354

13.

p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition.

Radhakrishnan, Senthil K; den Besten, Willem; Deshaies, Raymond J.

Elife; 3: e01856, 2014.

Artículo en Inglés | MEDLINE | ID: mdl-24448410

14.

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.

den Besten, Willem; Verma, Rati; Kleiger, Gary; Oania, Robert S; Deshaies, Raymond J.

Nat Struct Mol Biol; 19(5): 511-6, S1, 2012 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-22466964

15.

Differential post-transcriptional regulation of two Ink4 proteins, p18 Ink4c and p19 Ink4d.

Forget, Antoine; Ayrault, Olivier; den Besten, Willem; Kuo, Mei-Ling; Sherr, Charles J; Roussel, Martine F.

Cell Cycle; 7(23): 3737-46, 2008 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-19029828

16.

Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3.

Kuo, Mei-Ling; den Besten, Willem; Thomas, Mary C; Sherr, Charles J.

Cell Cycle; 7(21): 3378-87, 2008 Nov 01.

Artículo en Inglés | MEDLINE | ID: mdl-18948745

17.

Cytokine-dependent imatinib resistance in mouse BCR-ABL+, Arf-null lymphoblastic leukemia.

Williams, Richard T; den Besten, Willem; Sherr, Charles J.

Genes Dev; 21(18): 2283-7, 2007 Sep 15.

Artículo en Inglés | MEDLINE | ID: mdl-17761812

18.

Myeloid leukemia-associated nucleophosmin mutants perturb p53-dependent and independent activities of the Arf tumor suppressor protein.

den Besten, Willem; Kuo, Mei-Ling; Williams, Richard T; Sherr, Charles J.

Cell Cycle; 4(11): 1593-8, 2005 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-16205118

19.

N-Terminal polyubiquitination of the ARF tumor suppressor, a natural lysine-less protein.

Kuo, Mei-Ling; den Besten, Willem; Sherr, Charles J.

Cell Cycle; 3(11): 1367-9, 2004 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-15467472

20.

N-terminal polyubiquitination and degradation of the Arf tumor suppressor.

Kuo, Mei-Ling; den Besten, Willem; Bertwistle, David; Roussel, Martine F; Sherr, Charles J.

Genes Dev; 18(15): 1862-74, 2004 Aug 01.

Artículo en Inglés | MEDLINE | ID: mdl-15289458

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